Amine, Phenylamine or Aniline and Amide Reactions - Organic Chem

In this video we go through the 3 Must-Know Amine reactions, 3 Must-Know Phenylamine or Aniline reactions and 3 Must-Know Amide reactions.

Must-Know Amine Reaction:

1. Neutralisation reaction of amine to form ammonium salt using dilute sulphuric acid at room temperature

neutralisation of amine to form ammonium

2. Nucleophilic substitution of primary amine to form secondary amine using chloroalkane in ethanol, heat in sealed tube

nucleophilic substitution of primary amine to form secondary amine

3. Condensation of amine to form amide using acid chloride at room temperature

condensation of amine to form amide

Must-Know Phenylamine or Aniline Reaction:

1. Neutralisation reaction of phenylamine to form phenylammonium salt using dilute sulphuric acid at room temperature

neutralisation of phenylamine to form phenylammonium

2. Electrophilic substitution of phenylamine to form 2-bromophenylamine and 4-bromophenylamine using Br2 in organic solvent

electrophilic substitution of phenylamine to form monosubstituted products

3. Electrophilic substitution of phenylamine to form 2,4,6-tribromophenylamine using aqueous Br2 at room temperature

electrophilic substitution of phenylamine to form trisubstituted products

Must-Know Amide Reaction:

1. Acidic hydrolysis of amide to form carboxylic acid and ammonium salt using dilute sulphuric acid, heat or reflux

acidic hydrolysis of amide

2. Alkaline hydrolysis of amide to form salt of carboxylic acid and ammonia or amine using dilute sodium hydroxide, heat or reflux

alkaline hydrolysis of amide

3. Reduction of amide to form amine using lithium aluminium hydride in dry ether, followed by water at room temperature

reduction of amide

Memorising the reagents and conditions for these nitrogen compound reactions is an integral part of Organic Chemistry, so I've added a short memory test.

Let's see if you can remember all of them!

Topic: Nitrogen Compounds, Organic Chemistry, A Level Chemistry, Singapore

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